HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-(2-Bromoethyl)indolin-1-yl)ethanone → 7-(4-(2-(1-Acetylindolin-5-yl)ethyl)piperazin-1-yl)-5-fluoro-N,N-dimethylbenzofuran-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-(2-Bromoethyl)indolin-1-yl)ethanone | HCID 51713236 | — |
| Reactant | 5-fluoro-N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide | HCID 59636725 | — |
| Product | 7-(4-(2-(1-Acetylindolin-5-yl)ethyl)piperazin-1-yl)-5-fluoro-N,N-dimethylbenzofuran-2-carboxamide | HCID 59636778 | — |
Reaction Steps
The compound was prepared according to the procedure disclosed in Example 50 starting from 5-fluoro-N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.10 g, 0.35 mmol) (Example 50g) and 1-(5-(2-bromoethyl)indolin-1-yl)ethanone (0.13 g, 0.49 mmol) (Example 49b). The product was purified by preparative HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367676B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-ea8f4e49f220476a97feea961d8784e0 |
| Source note | uspto-grants-2013_02 |