HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Azabicyclo[2.2.1]heptan-3-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Azabicyclo[2.2.1]heptan-3-one | HCID 10855407 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Azabicyclo[2.2.1]heptan-3-ol hydrochloride | HCID 68594155 | — |
Reaction Steps
A mixture of 1-azabicyclo[2.2.1]heptan-3-one (Journal of Medicinal Chemistry, 1990, 33, pp. 2690-2697), hydrochloride (350 mg), platinum oxide (35 mg), and EtOH (5 mL) was stirred at room temperature under a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure to obtain 1-azabicyclo[2.2.1]heptan-3-ol hydrochloride as a pale brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367696B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-91301bffe9f34608abe4a4981fa409e6 |
| Source note | uspto-grants-2013_02 |