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Methanol → 4-Oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Succinic anhydride | HCID 7922 | — |
| 反応物 | 3-(Trifluoromethyl)benzylamine | HCID 75962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-Oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid | HCID 43397104 | 44.2% |
反応手順
A solution of 15.0 g (85.6 mmol) of (3-(trifluoromethyl)phenyl)methylamine in ether (40 ml) was added dropwise to a suspension of 7.5 g (85.6 mmol) of succinic anhydride in ether (450 ml) within 30 min. The mixture was then stirred for 72 h at room temperature. The deposit obtained was filtered and dried. After column chromatography (EE/MeOH 1:1) of the residue, 10.4 g (37.8 mmol, 44%) of 4-oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08367700B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-c4e7352f5de849dca980d4cce877ddc6 |
| 出典メモ | uspto-grants-2013_02 |