反应详情

0.65 g (17.1 mmol) of NaBH4 were added in portions to a solution of 3.2 g (max. 14.2 mmol) of the crude product 7-fluoro-1-phenyl-3,4-dihydroisoquinoline in EtOH (80 ml) and the mixture was then stirred for 16 h at RT. Then the mixture was concentrated to small volume under vacuum and the residue was taken up with DCM (200 ml). It was washed with water and the aqueous phase was extracted with DCM (2×150 ml). The combined organic phases were washed with brine, dried over Na2SO4, filtered and concentrated to small volume under vacuum. 7-Fluoro-1-phenyl-1,2,3,4-tetrahydroisoquinoline was obtained as the crude product, which was reacted further with no additional purification.

1. concentrationThen the mixture was concentrated to small volume under vacuum
2. washIt was washed with water
3. extractionthe aqueous phase was extracted with DCM (2×150 ml)
4. washThe combined organic phases were washed with brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. concentrationconcentrated to small volume under vacuum