反应详情

In a reaction vessel, 2-[4-(2-hydroxy-ethyl)-phenyl]-2-methyl-propionic acid methylester (1 g) prepared in the Examples 1-3, thionyl chloride (2.7 g) and dichloromethane (15 mL) were introduced, and the mixture was reacted at room temperature for 2 hours. Toluene (30 mL) was added, the mixture was condensed under reduced pressure, and the solvent was removed. Dichloromethane (50 mL) and sodium hydrogen carbonate solution (30 mL) were added thereto, and the mixture was stirred to separate layers. The separated organic layer was dehydrated with Na2SO4, and then condensed by filtration to obtain 2-[4-(2-chloro-ethyl)-phenyl]-2-methyl-propionic acid methylester (1.0 g, yield 92%).

1. additionwere introduced
2. customthe mixture was reacted at room temperature for 2 hours
3. customcondensed under reduced pressure
4. customthe solvent was removed
5. additionDichloromethane (50 mL) and sodium hydrogen carbonate solution (30 mL) were added
6. customto separate layers
7. customcondensed
8. filtrationby filtration