Dichloromethane → HCID 58169901, compound

Participants

Reaction Steps

To a solution of methyl(2S,5S,7R)-8-{[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate (Intermediate 13, 12 g, 19.88 mmol) in dry Dichloromethane (DCM) (80 ml) TEA (4.16 ml, 29.8 mmol) and then BOC-Anhydride (5.54 ml, 23.86 mmol) were added and the reaction mixture was stirred overnight at r.t. The reaction was diluted with NaHCO3 sat. sol. (400 ml) and two phases were separated. The organic layer was dried (Na2SO4), filtered and evaporated in vacuo and the residue was purified by flash chromatography on silica gel using a Biotage 65i as column and Cyclohexane to Cyclohexane/Ethyl acetate 7:3 as eluent affording the title compound (12.2 g, 17.43 mmol, y=87.7%).

Provenance & Evidence