Hydrochloric Acid → HCID 86684789, compound

Participants

Reaction Steps

To a cold (0° C.) solution of (2S,5S,7R)—N8-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide (Example 5, 21 mg, 0.036) in Diethyl ether (1 mL) was added 1N HCl in Diethyl ether (60 μl, 0.060 mmol) and the reaction mixture was stirred for 30 mins. The solvent was evaporated to dryness to give the title compound (23.8 mg, quantitative yield) as a white solid. 1H NMR (500 MHz, DMSO-d6) δ ppm 7.61-8.07 (m, 5H) 7.11-7.24 (m, 1H) 6.91-6.99 (m, 1H) 6.79-6.90 (m, 1H) 5.23-5.34 (m, 1H) 4.13-4.31 (m, 2H) 3.26-3.47 (m, 1 H) 2.79-2.92 (m, 1H) 2.70-2.79 (m, 3H) 1.79-2.66 (m, 11H) 1.38-1.54 (m, 3H). Presence of acid protons in the region between 8.30 and 9.66 ppm.

Provenance & Evidence