Hydrochloric Acid → HCID 86684790, compound

Participants

Reaction Steps

To a solution of (2R,5S,7R)—N8-{[3,5-bis(trifluoromethyl)phenyl]methyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide (Example 7, 45.5 mg, 0.079 mmol) in Diethyl ether (1 ml) was added 1M HCl in Et2O (0.107 mL, 0.107 mmol) and the resulting mixture was stirred for 30 mins. The solvent was evaporated to give the title compound (40 mg, 0.065 mmol, 82% yield) as a white foam. 1H NMR (500 MHz, DMSO-d6) δ ppm 9.49-9.85 (m, 1H) 8.36-8.60 (m, 1H) 7.96 (s, 1H) 7.92 (br. s., 1 H) 7.69 (br. s., 1H) 7.61 (s, 2H) 7.16-7.27 (m, 1H) 6.96 (d, 1H) 6.84 (t, 1H) 4.65 (d, 1 H) 4.35 (d, 1H) 4.24-4.32 (m, 1H) 4.20 (dd, 1H) 3.47 (d, 1H) 2.95 (s, 3H) 2.79 (t, 1H) 2.41-2.57 (m, 1H) 2.36 (s, 3H) 1.75-2.23 (m, 7H); HPLC: Rt 4.84 mins (free base); MS: m/z=575 [M+H]+ (free base).

Provenance & Evidence