Hydrochloric Acid → HCID 86651618, compound

Participants

Reaction Steps

To a solution of (2S,5S,7R)—N8-{[3,5-bis(trifluoromethyl)phenyl]methyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide (Example 9, 66 mg, 0.115 mmol) in Diethyl ether (1 ml) was added 1M HCl in Et2O (0.2 ml, 0.200 mmol) and the resulting mixture was stirred for 30 mins. The solvent was evaporated to dryness to give the title compound (61.7 mg, 0.101 mmol, 88% yield). 1H NMR (500 MHz, DMSO-d6) δ ppm 9.50-9.86 (m, 1H) 8.25-8.50 (m, 1H) 7.87-8.01 (m, 2H) 7.67 (s, 1H) 7.60 (s, 2H) 7.20-7.29 (m, 1H) 6.90-7.00 (m, 1H) 6.80-6.90 (m, 1H) 4.58-4.70 (m, 1H) 4.31-4.43 (m, 1H) 4.13-4.30 (m, 2H) 3.42-3.54 (m, 1H) 2.95 (s, 3H) 2.75-2.88 (m, 1H) 1.74-2.67 (m, 11H). HPLC: Rt=4.82 mins (free base); MS: m/z=575 [M+H]+ and 597 [M+Na]+ (free base).

Provenance & Evidence