Hydrochloric Acid → HCID 86651619, compound

Participants

Reaction Steps

To a solution of (2R,5S,7R)—N8-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-7-(4-fluoro-2-methylphenyl)-N8-methyl-1,8-diazaspiro[4.5]decane-2,8-dicarboxamide (Example 11, 54 mg, 0.092 mmol) in Diethyl ether (1 ml) was added 1M HCl in Et2O (200 μL, 0.200 mmol) and the resulting mixture was stirred for 30 mins. Then the solvent was evaporated to dryness to give the title compound (57.4 mg, 0.091 mmol, 99% yield). 1H NMR (500 MHz, DMSO-d6) δ ppm 9.35-9.68 (m, 1H) 8.35-8.60 (m, 1H) 7.95 (s, 1H) 7.90 (br. s., 1H) 7.70 (br. s., 1H) 7.56 (s, 2H) 7.11-7.25 (m, 1H) 6.94 (d, 1H) 6.80 (t, 1H) 5.28-5.39 (m, 1H) 4.13-4.35 (m, 2H) 3.44 (d, 1H) 2.85 (s, 3H) 2.77 (t, 1H) 2.40-2.59 (m, 1H) 2.35 (s, 3H) 1.75-2.21 (m, 7H) 1.50 (d, 3H); HPLC: Rt=4.95 mins (free base); MS: m/z=589 [M+H]+ (free base)

Provenance & Evidence