Hydrochloric Acid → HCID 178515651, compound

Participants

Reaction Steps

To a solution of ethyl 3-(4-(benzyloxy)phenyl)-2-propinoate (1.46 g) in methanol (30 ml), 1.45 g of hydroxyamine hydrochloride and 6.25 ml of 5M potassium hydroxide methanol were added, and the reaction solution was stirred overnight at room temperature. The solvent was distilled off under reduced pressure, the residue obtained was suspended in water, and the suspension was adjusted to pH 2-3 with a 2N aqueous hydrochloric acid solution. The resultant solid was obtained by filtration to afford the title compound as a light brown solid.

Provenance & Evidence