反应详情

To a solution of 2-hydroxynicotinic acid (3.0 g) in methanol 15 ml, 1 ml of concentrated sulfuric acid was added, and the reaction solution was heated to reflux for 2 hours. The reaction solution was cooled, then the solvent was distilled off under reduced pressure, and the residue obtained was diluted with water and extracted with chloroform. The combined organic layers were washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to afford the title compound as a pale pink solid.

1. temperaturethe reaction solution was heated
2. temperatureto reflux for 2 hours
3. temperatureThe reaction solution was cooled
4. distillationthe solvent was distilled off under reduced pressure
5. customthe residue obtained
6. extractionextracted with chloroform
7. washThe combined organic layers were washed with a saturated aqueous sodium bicarbonate solution
8. dry with materialdried over anhydrous sodium sulfate
9. distillationThe solvent was distilled off under reduced pressure