Methanol → HCID 178515650, compound

Participants

Reaction Steps

To a solution of 5-(4-((5-phenylisoxazol-3-yl)methoxy)phenyl)isoxazol-3-ylpivalate (21 mg) in methanol (2 ml), 0.4 ml of 5M potassium hydroxide methanol solution was added, and the reaction solution was stirred at room temperature for 1 hour. The reaction solution was neutralized, then extracted with chloroform, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified through reversed phase medium pressure liquid chromatography (ODS-AS-360-CC (by YMC), mobile phase: water-acetonitrile-0.1% trifluoroacetic acid). The solvent of the resultant fraction was distilled off under reduced pressure to afford the title compound as a white solid.

Provenance & Evidence