Pivaloyl chloride → HCID 68428320, compound

Participants

Reaction Steps

To a solution of 5-(4-(2-(3-nitrophenyl)ethoxy)phenyl)isoxazol-3-ol (117 mg) obtained in Example 37 in chloroform (5 ml), 0.15 ml of triethylamine and 0.052 ml of pivaloyl chloride were added, and the reaction solution was stirred at room temperature for 2 hours. The reaction solution was diluted with ethyl acetate, washed with a saturated saline solution, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by silica gel column chromatography (eluent: ethyl acetate/hexane (0:1-1:3)) to afford the title compound as a white solid.

Provenance & Evidence