Acetic Acid → HCID 68430972, compound

Participants

Reaction Steps

To a solution of 5-(4-(2-(3-aminophenyl)ethoxy)phenyl)-3-isoxazolyl pivalate (27.6 mg) in methanol (1 ml), 0.020 ml of acetone, 19.2 mg of sodium cyanoborohydride and 0.05 ml of acetic acid were added, and the reaction solution was stirred at room temperature for 2 hours. The reaction solution was diluted with saturated aqueous hydrogen carbonate sodium, extracted with chloroform, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by preparative thin layer chromatography (Kieselgel™ 60 F254, Art5744, made by Merck & Co., ethyl acetate/hexane (50:50)) to afford the title compound as a colorless oil.

Provenance & Evidence