Citric Acid → HCID 178437347, compound

Participants

Reaction Steps

To a mixed solution of ethyl 3-(4-(2-(3-methoxyphenyl)ethoxy)phenyl)propionate (75 mg) in tetrahydrofuran (1 ml) and ethanol (0.5 ml), 0.041 ml of hydroxylamine (50% aqueous solution) and 0.277 ml of 2.5N aqueous sodium hydroxide were added, and the reaction solution was stirred overnight at room temperature. To the reaction solution was added 10% aqueous citric acid, and the mixture was extracted with chloroform and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by preparative thin layer chromatography (Kieselgel™ 60 F254, Art5744, made by Merck & Co., ethyl acetate/hexane (25:75)) to afford the title compound as a white solid.

Provenance & Evidence