Citric Acid → HCID 15700705, compound

Participants

Reaction Steps

To a solution of 4-iodophenol (1.0 g) in dimethylformamide (10 ml), 273 mg of sodium hydride and 0.603 ml of 1,3-dibromopropane were added under ice-cooling, and the reaction solution was stirred at room temperature for 1 hour. To the reaction solution was added 10% aqueous citric acid, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with a saturated saline solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by silica gel column chromatography (eluent: hexane/ethyl acetate (98:2-50/50)) to afford the title compound as a colorless oil.

Provenance & Evidence