Hydrochloric Acid → HCID 178479552, compound

Participants

Reaction Steps

A suspension of 1.85 g (0.40 mmol) of 4-{3-[3-(2-fluoro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide in 40 ml of ethanol is stirred at ambient temperature under an argon atmosphere. Then 20 ml (40 mmol) of a solution of hydrochloric acid in diethyl ether (1 N) are added dropwise. The reaction medium becomes a clear solution. After stirring for 12 hours at ambient temperature, the solvents are evaporated using a rotary evaporator under reduced pressure. The residue obtained is stirred in 200 ml of diethyl ether for 30 minutes.

Provenance & Evidence