HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → ethyl 2-chloro-4-((1-methyl-1H-pyrazol-4-yl)methylamino)pyrimidine-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Ethyl 2,4-dichloropyrimidine-5-carboxylate | HCID 104020 | — |
| Reactant | (1-methyl-1H-pyrazol-4-yl)methanamine | HCID 671225 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | ethyl 2-chloro-4-((1-methyl-1H-pyrazol-4-yl)methylamino)pyrimidine-5-carboxylate | HCID 58098673 | — |
Reaction Steps
To a solution of ethyl 2,4-dichloropyrimidine-5-carboxylate (896 mg, 4 mmol) and (1-methyl-1H-pyrazol-4-yl)methanamine (445 mg, 4 mmol) in CH3CN (6 mL) at room temperature, DIEA (0.783 mL, 4.4 mmol) was added. The mixture was stirred at room temperature for 24 h, and was concentrated to give ethyl 2-chloro-4-((1-methyl-1H-pyrazol-4-yl)methylamino)pyrimidine-5-carboxylate as crude oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367689B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-dccdebbb7ab3451aaf1cbe32fd927991 |
| Source note | uspto-grants-2013_02 |