Boron tribromide → 4-(3-amino-2-hydroxy-phenyl)-1H-pyrrole-2-carboxylic acid

Participants

Reaction Steps

To a solution of 4-(3-amino-2-methoxy-phenyl)-1H-pyrrole-2-carboxylic acid 57h (130 mg, 0.56 mmol) in 2 mL of dichloromethane was added boron tribromide (1.12 mL, 2.24 mmol). The reaction mixture was stirred at room temperature for 6 hours. The reaction was monitored by TLC until the disappearance of the starting materials and quenched with methanol. The mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to obtain the title compound 4-(3-amino-2-hydroxy-phenyl)-1H-pyrrole-2-carboxylic acid 57i (140 mg, yield 99%) as a grey solid.

Provenance & Evidence