Benzoic Acid → Tolterodine Benzoate

Participants

Reaction Steps

3.25 g of tolterodine dissolved in 50 mL of acetone was mixed at room temperature (25° C.) with 1.22 g of benzoic acid, which was suspended in 50 mL of acetone, and then stirred. In 10 minutes, there started to appear a solid precipitate. 50 mL of acetone was added thereto and the mixture was stirred at room temperature (25° C.) for 1 hour. The resulting solid precipitate temperature (25° C.) for 24 hours and 3.27 g (theoretical yield: 73.1%) of the final product in white solid was obtained.

Provenance & Evidence