反应详情

3-Sulfanylphenol (250 mg) was dissolved in methanol (5 mL), and a 28% sodium methoxide-methanol solution (0.5 mL) was added thereto, followed by stirring at room temperature for 10 minutes. 4-(Bromomethyl)tetrahydro-2H-pyrane (410 mg) was added to the reaction mixture, followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and then water was added to the residue, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine and dried. The solvent was evaporated under reduced pressure, and the residue was washed with hexane to obtain 3-[(tetrahydro-2H-pyran-4-ylmethyl)sulfanyl]phenol (265 mg).

1. stirringby stirring at room temperature for 3 hours
2. customThe solvent was evaporated under reduced pressure
3. additionwater was added to the residue
4. extractionfollowed by extraction with ethyl acetate
5. washThe organic layer was washed with saturated brine
6. customdried
7. customThe solvent was evaporated under reduced pressure
8. washthe residue was washed with hexane