Hydrochloric Acid → HCID 58380917, compound

Participants

Reaction Steps

To a solution of 2-methyl-propane-2-sulfinic acid [5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-adamantan-2-yl]-amide (6) in 2-propanol (10 mL) was added 1N hydrochloric acid (5 mL) and the mixture was stirred at room temperature until complete conversion was achieved. The reaction mixture was washed with diethyl ether, the aqueous phase was concentrated in vacuo and lyophilized to yield 676 mg of a diastereomeric mixture of 4-phenyl-4-amino-adamantan-1-ol (7) as its hydrochloride. Rt=0.33 min, 0.85 min (Method 3). Detected mass: 227.2 (M-NH3+H+).

Provenance & Evidence