反应详情

To an ice-cold solution of 2-(aminomethyl)-3-methylquinolin-4(1H)-one dihydrochloride (160 mg) in pyridine (5 mL) was added heptanoic acid chloride (110 mg), and the mixture was stirred at room temperature for 45 minutes. The reaction mixture was concentrated under reduced pressure, and then water (40 mL) was added to the residue. The resulting solid was collected by filtration, washed with water, and dried. This solid was purified by silica gel column chromatography (eluent: chloroform/methanol=20/1) to obtain N-[(3-methyl-4-oxo-1,4-dihydroquinolin-2-yl)methyl]heptanamide (127 mg).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionwater (40 mL) was added to the residue
3. filtrationThe resulting solid was collected by filtration
4. washwashed with water
5. customdried
6. customThis solid was purified by silica gel column chromatography (eluent: chloroform/methanol=20/1)