Diglycolamine → 1-(2-(2-Hydroxy-ethoxy)-ethylamino)-3-(3-(1,1,3,3-tetramethyl-3-(2-trimethylsilanyl-ethyl)-disiloxanyl)-propoxy)-propan-2-ol
Reaction equation
[NH2:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][OH:7].[CH3:8][Si:9]([CH3:28])([CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[O:10][Si:11]([CH3:21])([CH3:20])[CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH:17]1[CH2:19][O:18]1>C(O)C>[OH:7][CH2:6][CH2:5][O:4][CH2:3][CH2:2][NH:1][CH2:19][CH:17]([OH:18])[CH2:16][O:15][CH2:14][CH2:13][CH2:12][Si:11]([CH3:20])([CH3:21])[O:10][Si:9]([CH3:28])([CH3:8])[CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
2-(2-Amino-ethoxy)-ethanol (3.02 g) and ethanol (40 mL) were charged to a 100 mL RB flask equipped with a magnetic stirrer. The mixture was stirred and heated to 70° C. 1,1,3,3-Tetramethyl-3-(3-oxiranylmethoxy-propyl)-1-(2-trimethylsilanyl-ethyl)-disiloxane (2.0 g) mixed with ethanol (10 mL) was placed in an addition funnel and added dropwise to the flask. The mixture was stirred and maintained at 70° C. for an additional 4 hours. The reaction progress was monitored by NMR spectroscopy. Upon reaction completion, ethanol was removed under vacuum, and the mixture was vacuum distilled to remove impurities and excess raw material.
Workup
- customequipped with a magnetic stirrer
- customwas placed in an addition funnel
- additionadded dropwise to the flask
- stirringThe mixture was stirred
- temperaturemaintained at 70° C. for an additional 4 hours
- customwas removed under vacuum
- distillationdistilled
- customto remove impurities and excess raw material
Sources & evidence
- ORD record
- ord-d8264dfca34646acb358c57894d2ed96
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08367740B2
Reaction notes
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