1,2-Dimethoxyethane → 2-Hydroxy-1-[4-(2-{2-hydroxy-3-[(2-hydroxy-3-{2-[4-(2-hydroxy-2-methylpropionyl)phenoxy]ethoxy}propyl)-(3-triethoxysilylpropyl)amino]-propoxy}ethoxy)phenyl]-2-methylpropan-1-one

Participants

Reaction Steps

To a mixture of 5.09 g (23 mmol) of 3-aminopropyltriethoxysilane, 30 ml of 1,2-dimethoxyethane and 30 ml of 2-propanol is added 8.99 g (32.1 mmol) of the compound prepared in Example 1A. The reaction mixture is heated at a gentle reflux for 23 hours. Solvent is evaporated to afford 14.37 g of a pale yellow oil corresponding to a mixture of the title compounds.

Provenance & Evidence