Trimethyl phosphite → HCID 57661178, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.80 grams (0.0202 mol) of 1-[4-(2-bromoethoxy)phenyl]-2-hydroxy-2-methylpropan-1-one and 6.27 g (0.0505 mol) of trimethyl phosphite is heated to 130° C. for 16 hours. The crude product is passed through a short column of silica gel which is eluted with a mixture of 1:1 heptane:ethyl acetate followed by methanol. Evaporation of solvent gives 3.5 g (55% yield) of the title compound as a yellow oil.

Provenance & Evidence