Hydrochloric Acid → HCID 68862180, compound

Participants

Reaction Conditions

Reaction Steps

2-Bromoethylbenzene (10.0 g, 0.0540 mol) is mixed with 6.6 g (0.062 mol) of isobutyryl chloride and 100 ml of 1,2-dichlorobenzene. The mixture is cooled internally to 0° C., and 9.4 g (0.070 mol) of aluminum chloride is added portion wise over 3 hours while keeping the reaction mixture at 0-5° C. The reaction mixture is stirred overnight, then poured into a mixture of ice and concentrated hydrochloric acid. After stirring for 30 minutes, the organic layer is washed with dilute hydrochloric acid, sodium bicarbonate solution, and water, then dried over sodium sulfate and concentrated to give 15.0 g of crude 1-[4-(2-bromoethyl)phenyl]-2-methylpropan-1-one.

Provenance & Evidence