Ethanol → HCID 68861821, compound

HRID 384592Notes

Reaction equation

HRID 384592 reaction equation
Br[C:2]([CH3:15])([CH3:14])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][Br:13])=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+].C([OH:20])C>COCCOC>[Br:13][CH2:12][CH2:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[C:2]([OH:20])([CH3:15])[CH3:14])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 68861002HCID 68861002, compound

Product 1

HCID 68861821HCID 68861821, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 5.0 g, 0.105 mol) of 2-bromo-1-[4-(2-bromo-ethyl)-phenyl]-2-methyl-propan-1-one, 0.60 g (0.015 mol) of sodium hydroxide, 100 ml of ethanol and 50 ml of 1,2-dimethoxyethane is stirred at room temperature overnight. The reaction mixture is concentrated and the crude product is dissolved in ethyl acetate. The solution is washed with distilled water, dried over sodium sulfate and concentrated to give 3.4 g of 1-[4-(2-bromoethyl)phenyl]-2-hydroxy-2-methylpropan-1-one.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. dissolutionthe crude product is dissolved in ethyl acetate
  3. washThe solution is washed with distilled water
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-69ca4f3c8bf24187829ded60987cbe09
Source dataset
uspto-grants-2013_02
Patent number
US08367743B2

Reaction notes

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