Triethyl phosphite → HCID 57661169, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 10 g of 1-[4-(2-bromoethyl)phenyl]-2-hydroxy-2-methylpropan-1-one (0.037 moles) and 6.7 g (0.041 mol) of triethyl phosphite is heated externally at 140° C. for 24 hours. The reaction mixture is distilled to give 12.1 g of 2-[4-(2-hydroxy-2-methylpropionyl)phenyl]ethyl}phosphonic acid dimethyl ester. The ester is dissolved in 50 ml of dichloromethane, and a solution of 6.2 g (0.0405 mol) of trimethylsilyl bromide in 10 ml of dichloromethane is added drop wise at room temperature. The reaction mixture is stirred overnight. The reaction mixture is concentrated, and methanol (200 ml) is added. The mixture is stirred at temperature for 24 hours, and then concentrated to give 5.0 g of the title compound, a yellow oil.

Provenance & Evidence