Triethyl phosphite → HCID 86629706, compound

Participants

Reaction Steps

1-(4-{3-Bromo-1-[4-(2-hydroxy-2-methylpropionyl)phenyl]propyl}phenyl)-2-hydroxy-2-methylpropan-1-one (5.0 g, 0.0112 moles) is reacted with 4.6 grams of triethyl phosphite following the procedure of Example 23 to give 5.7 g (98% yield) of {3,3-bis-[4-(2-hydroxy-2-methylpropionyl)phenyl]propyl}phosphonic acid dimethyl ester, a yellow oil. The ester is reacted with trimethylsilyl bromide in chloroform and methanol, following the procedure of Example 22, to give 5.0 g of the title compound, an amorphous solid.

Provenance & Evidence