Water → HCID 57661144, compound

Participants

Reaction Steps

A mixture of 64.0 g (0.164 mol) of 3-[4-(2-bromo-2-methylpropionyl)phenyl]-3-phenylpropanoate, 13.2 g (0.328 mol) of sodium hydroxide, 70 ml of water, and 300 ml of 1,2-dimethoxyethane is heated at reflux for 16 hours. The reaction is concentrated, and then acidified with 25 ml of 1.5 N hydrochloric acid solution. Ethyl acetate (200 ml) is added, and the organic layer is washed with distilled water, dried over sodium sulfate, and concentrated. The crude product is passed through a pad of silica gel with ethyl acetate as the eluent to give 44 g (86% yield) of the title compound.

Provenance & Evidence