1,2-Dichloroethane → HCID 59402226, compound

Participants

Reaction Steps

(S)-2-amino-N-(5-chloro-2-(1H-tetrazol-1-yl)phenethyl)-3-phenylpropanamide: To a mixture of 2-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)ethanamine (0.179 g, 0.8 mmol), (S)-2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid (0.233 g, 0.880 mmol), EDC (0.169 g, 0.880 mmol) and HOBt (0.135 g, 0.880 mmol) in DMF (10 mL) was added DIEA (excess, 1.0 mL). The resulted mixture was stirred at rt for 2.5 h. Most of the solvent was removed and the residue was diluted with ethyl acetate, washed with water, 1N HCl, sat. NaHCO3, brine and dried over anhydrous MgSO4 to obtain the desired product as a white solid. LCMS m/z 471.4.

Provenance & Evidence