HCID 178479293, compound → 1H-Indazol-5-amine

HRID 384608Notes

Reaction equation

HRID 384608 reaction equation
[ClH:1].[NH:2]1[C:6]([C:7]2[CH:8]=[C:9]([NH:13][C:14](=[O:24])[C@@H:15]([NH2:23])[CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:10]=[CH:11][CH:12]=2)=[N:5][N:4]=[N:3]1.[NH:25]1[C:29]([C:30]2[CH:31]=[C:32]([CH:34]=[CH:35][CH:36]=2)[NH2:33])=NN=[N:26]1>>[Cl:1][C:36]1[CH:30]=[CH:31][C:32]([N:33]2[CH:6]=[N:2][N:3]=[N:4]2)=[C:34](/[CH:16]=[CH:15]/[C:14]([NH:23][C@H:15]([C:14](=[O:24])[NH:13][C:9]2[CH:10]=[CH:11][CH:12]=[C:7]([C:6]3[NH:2][N:3]=[N:4][N:5]=3)[CH:8]=2)[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:24])[CH:35]=1.[NH2:33][C:32]1[CH:31]=[C:30]2[C:36](=[CH:35][CH:34]=1)[NH:26][N:25]=[CH:29]2

Participants

4

Reactant 2

HCID 178479293HCID 178479293, compoundHCID 178507542HCID 178507542, compound

Product 2

HCID 880121H-Indazol-5-amineYield 49%HCID 178520474HCID 178520474, compound

Procedure

(S)—N-(3-(1H-tetrazol-5-yl)phenyl)-2-amino-3-phenylpropanamide hydrochloride: The title compound was prepared in a similar manner described for Examples 3 and 31 using 3-(1H-tetrazol-5-yl)aniline in place of 5-aminoindazole (49% yield). LCMS m/z 309 [M+H]+.

Sources & evidence

ORD record
ord-dc6ea73bade44ad0bfee36f4650aae67
Source dataset
uspto-grants-2013_02
Patent number
US08367709B2

Reaction notes

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