Hydrochloric Acid → HCID 59401936, compound

Participants

Reaction Steps

(S,E)-4-(4-(tert-butoxycarbonyl)phenylamino)-3-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-4-oxobutanoic acid: To a solution of 17A (1.8 g, 3.24 mmol) in THF (16 mL) was added lithium hydroxide monohydrate (0.30 g, 7.14 mmol) in H2O (16 mL). After 1 h, the reaction mixture was acidified to pH 5-6 with 1.0M HCl and extracted with EtOAc (3×40 mL). The combined organic extracts were dried over sodium sulfate, filtered, and concentrated to afford the desired product as an off-white solid. LCMS m/z 541 [M+H]+.

Provenance & Evidence