HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 384617Generated: October 31, 2026
Propylene Glycol → 2H-Azepin-2-one, 3-aminohexahydro-
https://huagongshe.com/reaction/384617
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propylene Glycol | HCID 1030 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | L-Lysine monohydrochloride | HCID 69568 | — |
| Product | 2H-Azepin-2-one, 3-aminohexahydro- | HCID 102463 | — |
Reaction Steps
300 mmols of L-lysine hydrochloride 1 is neutralized with 300 mmols of NaOH and then 1.2 L of 1,2-propanediol is added. This mixture is heated to 187° C. and is refluxed for 2 hours after removing about the 10% of the solvent when the reaction is first brought to reflux. The yield of α-amino-ε-caprolactam 2 produced by this reaction is about 96%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367819B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-57824a47e3ef42aeb3c3e82117fa383d |
|---|
| Source note | uspto-grants-2013_02 |
|---|
