HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 384619Generated: October 31, 2026
Sodium Hydroxide → 2H-Azepin-2-one, 3-aminohexahydro-
https://huagongshe.com/reaction/384619
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | L-Lysine monohydrochloride | HCID 69568 | — |
| Solvent | 1-Pentanol | HCID 6276 | — |
| Product | 2H-Azepin-2-one, 3-aminohexahydro- | HCID 102463 | — |
Reaction Steps
30 mmols of L-lysine hydrochloride 1 is neutralized with 30 mmols of NaOH and then 270 mmols of Al2O3 is added, followed by 120 ml of 1-pentanol. This mixture is heated to 137° C. and is refluxed for four hours. The yield of α-amino-ε-caprolactam 2 produced by this reaction is about 96%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08367819B2 |
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| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-eb6af4cd434540278bddefd096dd68a8 |
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| Source note | uspto-grants-2013_02 |
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