HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 384646Generated: October 29, 2026
Trifluoroacetic acid → HCID 42610782, compound
https://huagongshe.com/reaction/384646
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl-4-((6-(5-cyanopyrazin-2-ylamino)pyrimidin-4-ylamino)methyl)-piperidine-1-carboxylate | HCID 66746317 | — |
| Product | HCID 42610782 | HCID 42610782 | 15% |
Reaction Steps
A mixture of tert-butyl-4-((6-(5-cyanopyrazin-2-ylamino)pyrimidin-4-ylamino)methyl)-piperidine-1-carboxylate (0.15 mmol) and trifluoroacetic acid was heated at 82° C. for 4 hours. The solution was evaporated to dryness and the residue was purified by preparative HPLC to give 5-(6-(piperidin-4-ylmethylamino)pyrimidin-4-ylamino)pyrazine-2-carboxamide (7.36 mg, 15%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367658B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-29e210c2f0764a8496ab0843a399168d |
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| Source note | uspto-grants-2013_02 |
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