HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 384648Generated: October 27, 2026
2-Amino-5-bromopyrazine → 5-Methoxypyrazin-2-amine
https://huagongshe.com/reaction/384648
Participants
| Role | Name | HCID | Charge |
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| Reactant | 2-Amino-5-bromopyrazine | HCID 599539 | — |
| Reactant | Sodium methanolate methanol | HCID 23694274 | — |
| Product | 5-Methoxypyrazin-2-amine | HCID 14536429 | 32% |
Reaction Steps
5-Bromopyrazin-2-amine (0.11 g, 0.63 mmol) was dissolved in NaOMe/MeOH (0.23 g Na metal in 10 mL MeOH) and heated by microwave irradiation at 140° C. for 7 hours. After evaporation of the solvent, the residue was purified by preparative TLC, eluting with 30% ethyl acetate-n-hexane, to give 5-methoxypyrazin-2-amine (25 mg, 32%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367658B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-6fc3870c23204f16b893842c79a2e56d |
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| Source note | uspto-grants-2013_02 |
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