4-Methoxycarbonylphenylboronic acid → Methyl 3-(1-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}-1H-indol-4-yl)benzoate

Participants

Role	Name	HCID	Charge
Reactant	4-Methoxycarbonylphenylboronic acid	HCID 2734369	—
Reactant	3-(Methoxycarbonyl)benzeneboronic acid	HCID 2734714	—
Reactant	1-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}-1H-indol-4-yl trifluoromethanesulfonate	HCID 58208712	—
Product	Methyl 3-(1-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}-1H-indol-4-yl)benzoate	HCID 58208671	—

Reaction Steps

The intended compound was produced according to the procedure described in Example 28-1 but using 1-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4′-piperidin]-1′-yl]carbonyl}-1H-indol-4-yl trifluoromethanesulfonate and [3-(methoxycarbonyl)phenyl]boronic acid in place of 8-cyclopropyl-2-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4′-piperidin]-1′-yl]carbonyl}quinolin-4-yl trifluoromethanesulfonate and [4-(methoxycarbonyl)phenyl]boronic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08524730B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-aaeeccadf5634b4ea737260ae2686402
Source note	uspto-grants-2013_09