2,6-Diethoxy-3'-fluoro-4'-(methoxycarbonyl)biphenyl-4-carboxylic acid → Methyl 2',6'-diethoxy-3-fluoro-4'-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}biphenyl-4-carboxylate

Participants

Reaction Steps

In the same manner as in Reference Example 3-1, the intended compound was obtained as a colorless solid using 6-(1-methyl-1H-pyrazol-4-yl)spiro[chroman-2,4′-piperidin]-4-one hydrochloride and 2,6-diethoxy-3′-fluoro-4′-(methoxycarbonyl)biphenyl-4-carboxylic acid.

Provenance & Evidence