2,6-Diethoxy-4'-fluoro-3'-(methoxycarbonyl)biphenyl-4-carboxylic acid → Methyl 2',6'-diethoxy-4-fluoro-4'-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}biphenyl-3-carboxylate

HRID 38472Notes

Reaction equation

HRID 38472 reaction equation
Cl.[CH3:2][N:3]1[CH:7]=[C:6]([C:8]2[CH:9]=[C:10]3[C:20](=[CH:21][CH:22]=2)[O:19][C:13]2([CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH2:12][C:11]3=[O:23])[CH:5]=[N:4]1.[CH2:24]([O:26][C:27]1[CH:32]=[C:31]([C:33](O)=[O:34])[CH:30]=[C:29]([O:36][CH2:37][CH3:38])[C:28]=1[C:39]1[CH:44]=[CH:43][C:42]([F:45])=[C:41]([C:46]([O:48][CH3:49])=[O:47])[CH:40]=1)[CH3:25]>>[CH2:24]([O:26][C:27]1[CH:32]=[C:31]([C:33]([N:16]2[CH2:15][CH2:14][C:13]3([CH2:12][C:11](=[O:23])[C:10]4[C:20](=[CH:21][CH:22]=[C:8]([C:6]5[CH:5]=[N:4][N:3]([CH3:2])[CH:7]=5)[CH:9]=4)[O:19]3)[CH2:18][CH2:17]2)=[O:34])[CH:30]=[C:29]([O:36][CH2:37][CH3:38])[C:28]=1[C:39]1[CH:44]=[CH:43][C:42]([F:45])=[C:41]([C:46]([O:48][CH3:49])=[O:47])[CH:40]=1)[CH3:25]

Participants

3

Reactant 2

HCID 582086892,6-Diethoxy-4'-fluoro-3'-(methoxycarbonyl)biphenyl-4-carboxylic acidHCID 667825466-(1-Methyl-1H-pyrazol-4-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

Product 1

HCID 58208684Methyl 2',6'-diethoxy-4-fluoro-4'-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}biphenyl-3-carboxylate

Procedure

In the same manner as in Reference Example 3-1, the intended compound was obtained as a colorless solid using 6-(1-methyl-1H-pyrazol-4-yl)spiro[chroman-2,4′-piperidin]-4-one hydrochloride and 2,6-diethoxy-4′-fluoro-3′-(methoxycarbonyl)biphenyl-4-carboxylic acid.

Workup

  1. customIn the same manner as in Reference Example 3-1, the intended compound was obtained as a colorless solid

Sources & evidence

ORD record
ord-56c42ca27e0d4bf4acbb0d0c480613d0
Source dataset
uspto-grants-2013_09
Patent number
US08524730B2

Reaction notes

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