HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-methyl 2-amino-5-cyclopropyl-4,4-difluoropentanoate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-methyl 2-(benzyloxycarbonylamino)-5-cyclopropyl-4,4-difluoropentanoate | HCID 58350203 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (S)-methyl 2-amino-5-cyclopropyl-4,4-difluoropentanoate hydrochloride | HCID 66939849 | 98.8% |
Reaction Steps
A solution of (S)-methyl 2-(benzyloxycarbonylamino)-5-cyclopropyl-4,4-difluoropentanoate (570 mg, 1.87 mmol) in dioxane/4N—HCl (9 mL, 37 mmol) was stirred at RT for two hr, after which the solvent was removed by rotoevaporation to give 450 mg of (S)-methyl 2-amino-5-cyclopropyl-4,4-difluoropentanoate hydrochloride as a beige solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367732B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-eeec20e3327942e2a369dc1258ef7bc8 |
| Source note | uspto-grants-2013_02 |