反应详情

tert-butyl 2-(3-(6-(5-(N-tert-butylsulfamoyl)pyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)ureido)ethylcarbamate (35 mg) was suspended in HCl (4M in dioxane, 2 mL) and DCM (2 mL) and the reaction mixture stirred overnight at room temperature. After this time the reaction mixture was pippetted slowly onto diethyl ether at −78° C. and maintained at this temperature for 20 minutes. The resultant white solid was filtered, washed with further diethyl ether and dried under vacuum to afford the title compound (21 mg).

1. customwas pippetted slowly onto diethyl ether at −78° C.
2. temperaturemaintained at this temperature for 20 minutes
3. filtrationThe resultant white solid was filtered
4. washwashed with further diethyl ether
5. customdried under vacuum