Ammonium Chloride → Methyl 2-amino-4-(3-chloropropoxy)-5-methoxybenzoate

HRID 384748노트

반응식

HRID 384748 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[C:15]([O:16][CH3:17])=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[C:8]([N+:18]([O-])=O)[CH:7]=1.[Cl-].[NH4+]>O.CO.[Fe]>[NH2:18][C:8]1[CH:7]=[C:6]([O:5][CH2:4][CH2:3][CH2:2][Cl:1])[C:15]([O:16][CH3:17])=[CH:14][C:9]=1[C:10]([O:12][CH3:13])=[O:11]

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 23032992Methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate

생성물 1

HCID 23033013Methyl 2-amino-4-(3-chloropropoxy)-5-methoxybenzoate수율 90%

시약·촉매·용매 3

HCID 23925Iron촉매HCID 887Methanol용매HCID 962Water용매

실험 절차

JP-A-2001-519788 describes a process for preparing a 5-alkoxy-4-halogenoalkoxyanthranilic acid compound from a 5-alkoxy-4-halogenoalkoxy-2-nitrobenzoic acid compound. For example, methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate is reacted with a very excessive amount of iron and ammonium chloride in a mixture of water and methanol, to give methyl 2-amino-4-(3-chloropropoxy)-5-methoxybenzoate (i.e., ethyl 4-(3-chloropropoxy)-5-methoxyanthranilate) in 90% yield.

출처 및 근거

ORD 기록
ord-a366a0d28bb14f919f4316e07b79a59b
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367824B2

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