Methanol → 4(1H)-Quinazolinone

Participants

Reaction Steps

In a 2-mL volume stainless steel pressure-resistant vessel were placed 302 mg (2.0 mmol) of methyl anthranilate, 424 mg (4.0 mmol) of methyl orthoformate, 308 mg (4.0 mmol) of ammonium acetate, and 1.0 mL of methanol. The reaction was carried out at 120° C. for 3 hours. After the reaction was complete, the reaction mixture was analyzed (according to absolute quantitative analysis) by high performance liquid chromatography. There was produced 285 mg (reaction yield: 98%) of quinazolin-4-one.

Provenance & Evidence