Methanol → HCID 135589774, compound

Participants

Reaction Steps

In a 10-mL volume stainless steel pressure-resistant vessel were placed 0.65 g (2.5 mmol) of 5-nitro-4-(3-hydroxypropoxy)anthranilic acid, 1.06 g (10.0 mmol) of methyl orthoformate, 0.77 g (10.0 mmol) of ammonium acetate, and 6.0 mL of methanol. The reaction was carried out at 140° C. for 6.5 hours. After the reaction was complete, the reaction mixture was cooled to room temperature, and 50 mL of water was added to the reaction mixture. The precipitated crystalline product was collected by filtration and dried under reduced pressure to give 0.52 g (isolated yield: 79%) of 6-nitro-7-(3-hydroxypropoxy)quinazolin-4-one as a gray crystalline product.

Provenance & Evidence