1,4-Dioxane hydrochloride → 6-(1-Methyl-1H-pyrazol-4-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

HRID 38477Notes

Reaction equation

HRID 38477 reaction equation
[ClH:1].O1CCOCC1.[CH3:8][N:9]1[CH:13]=[C:12]([C:14]2[CH:15]=[C:16]3[C:33](=[CH:34][CH:35]=2)[O:32][C:19]2([CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]2)[CH2:18][C:17]3=[O:36])[CH:11]=[N:10]1>CCOCC>[ClH:1].[CH3:8][N:9]1[CH:13]=[C:12]([C:14]2[CH:15]=[C:16]3[C:33](=[CH:34][CH:35]=2)[O:32][C:19]2([CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[CH2:18][C:17]3=[O:36])[CH:11]=[N:10]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57931011Tert-Butyl 6-(1-methyl-1H-pyrazol-4-yl)-4-oxo-spiro[chroman-2,4'-piperidine]-1'-carboxylate

Product 1

HCID 667825466-(1-Methyl-1H-pyrazol-4-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4 N hydrogen chloride/dioxane solution was added to tert-butyl 6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate (1.00 g), and stirred overnight at room temperature. Ether was added to the reaction liquid, the resulted precipitate was taken out through filtration, washed with ether, and dried under reduced pressure to obtain the intended compound as a colorless solid.

Workup

  1. filtrationthe resulted precipitate was taken out through filtration
  2. washwashed with ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-e0bdefaa3630425d95535a4eaec63093
Source dataset
uspto-grants-2013_09
Patent number
US08524730B2

Reaction notes

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