HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)nicotinamide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | tert-Butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate | HCID 58208682 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)nicotinamide dihydrochloride | HCID 66781884 | — |
Reaction Steps
To a suspension of tert-butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate in dioxane (125 ml) was added 4N HCl in dioxane (125 ml) and the mixture was stirred for 18 h. After Et2O was added to the mixture, the resulted precipitate was collected by aeration, washed with Et2O to give intended compound as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524730B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-6add63eca05c4a7ea8bd746aa231ffd3 |
| Source note | uspto-grants-2013_09 |