Methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate → Methyl 2-amino-4-(3-chloropropoxy)-5-methoxybenzoate

HRID 384795Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 384795
[H][H].[CH3:3][O:4][C:5]1[C:6]([O:18][CH2:19][CH2:20][CH2:21][Cl:22])=[CH:7][C:8]([N+:15]([O-])=O)=[C:9]([CH:14]=1)[C:10]([O:12][CH3:13])=[O:11]>[Pt]=S.[C].CO>[CH3:3][O:4][C:5]1[CH:14]=[C:9]([C:10]([O:12][CH3:13])=[O:11])[C:8]([NH2:15])=[CH:7][C:6]=1[O:18][CH2:19][CH2:20][CH2:21][Cl:22]

Komponenten

5

Edukt 2

HCID 23032992Methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 23033013Methyl 2-amino-4-(3-chloropropoxy)-5-methoxybenzoateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178505369HCID 178505369, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

In a 50 mL volume glass flask equipped with a stirrer, a thermometer, a reflux condenser and a balloon containing hydrogen gas were placed 1.01 g (3.29 mmol) of methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate (purity: 99%) obtained in Reference Example III-4, 0.2 g of 3 wt. % platinum sulfide/carbon (containing 65.7% water), and 40 mL of methanol. The reaction was carried out at 40° C. for 8 hours. After the reaction was complete, the reaction mixture was filtered. The filtrate was analyzed by high performance liquid chromatography (absolute quantitative analysis). There was produced 0.88 g (reaction yield: 98.0%) of methyl 5-methoxy-4-(3-chloropropoxy)anthranilate.

Aufarbeitung

  1. customIn a 50 mL volume glass flask equipped with a stirrer
  2. filtrationthe reaction mixture was filtered

Quellen und Nachweise

ORD-Eintrag
ord-8979d654bbf3409fa99e90303d311e41
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367824B2

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